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1959 1
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2000 3
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2002 2
2003 2
2004 2
2005 4
2006 4
2007 5
2008 3
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141 results

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Page 1
Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients.
Veleri S. Veleri S. Exp Brain Res. 2022 Jan;240(1):9-25. doi: 10.1007/s00221-021-06244-z. Epub 2021 Oct 25. Exp Brain Res. 2022. PMID: 34694467 Free PMC article. Review.
The SARS-CoV-2 elicited immune response and host immune response evasion are further discussed. Then the effects on the nervous system and its consequences on neuro-sensory functions are discussed. ...
The SARS-CoV-2 elicited immune response and host immune response evasion are further discussed. Then the effects on the nervou …
Alimentary system is directly attacked by SARS-COV-2 and further prevents immune dysregulation caused by COVID-19.
Chen S, Zhou J, Ou X, Cheng W, Qin Y, Guo Y, Jiang Y. Chen S, et al. Int J Clin Pract. 2021 Apr;75(4):e13893. doi: 10.1111/ijcp.13893. Epub 2020 Dec 31. Int J Clin Pract. 2021. PMID: 33289233

Respiratory system symptom and asymptomatic groups suffered the most from lymphocyte depletion (P < .05). ...CTSL, PIKfyve, TPC2 and CTSB could be detected with moderate expressions in a variety of organs including alimentary system. CONCLUSIONS: Alimentary sy

…

Respiratory system symptom and asymptomatic groups suffered the most from lymphocyte depletion (P < .05). ...CTSL, PIKfyve, TPC2 a

…
Harnessing proteases for T regulatory cell immunotherapy.
Amarnath S, Brown ML. Amarnath S, et al. Eur J Immunol. 2020 Jun;50(6):770-778. doi: 10.1002/eji.201948270. Epub 2020 May 18. Eur J Immunol. 2020. PMID: 32383480 Free article. Review.
The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune homeostasis by restraining unwarranted immune cell activation and effector function. ...
The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune …
The role of BAFF and APRIL in rheumatoid arthritis.
Shabgah AG, Shariati-Sarabi Z, Tavakkol-Afshari J, Mohammadi M. Shabgah AG, et al. J Cell Physiol. 2019 Aug;234(10):17050-17063. doi: 10.1002/jcp.28445. Epub 2019 Apr 2. J Cell Physiol. 2019. PMID: 30941763 Review.
B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are the members of membrane proteins Type 2 family released by proteolytic cleavage of furin to form active, soluble homotrimers. Except for B cells, ligands are expressed by all such immune …
B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are the members of membrane proteins Type 2 family released by p …
FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice.
Ojanen MJT, Caro FM, Aittomäki S, Ploquin MJ, Ortutay Z, Pekkarinen M, Kesseli J, Vähätupa M, Määttä J, Nykter M, Junttila IS, Järvinen TAH, O Shea JJ, Biron CA, Pesu M. Ojanen MJT, et al. Eur J Immunol. 2023 Jun;53(6):e2250246. doi: 10.1002/eji.202250246. Epub 2023 Apr 28. Eur J Immunol. 2023. PMID: 37015057
FURIN has also important regulatory functions in both innate and adaptive immune responses but its role in the CD8(+) CTLs remains enigmatic. ...We also characterized Furin KO CD8(+) T cells ex vivo, including after their activation with FURIN regulati …
FURIN has also important regulatory functions in both innate and adaptive immune responses but its role in the CD8(+) CTLs rem …
What Are the Roles of Proprotein Convertases in the Immune Escape of Tumors?
Mehranzadeh E, Crende O, Badiola I, Garcia-Gallastegi P. Mehranzadeh E, et al. Biomedicines. 2022 Dec 19;10(12):3292. doi: 10.3390/biomedicines10123292. Biomedicines. 2022. PMID: 36552048 Free PMC article. Review.
One of the most important components of the TME is the immune system of the tumor. In this review, we describe recent discoveries that link PCs to the immune escape of tumors. ...The impacts of other PCs in tumor immune escape have not yet been clarifi …
One of the most important components of the TME is the immune system of the tumor. In this review, we describe recent discover …
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
Torre-Fuentes L, Matías-Guiu J, Hernández-Lorenzo L, Montero-Escribano P, Pytel V, Porta-Etessam J, Gómez-Pinedo U, Matías-Guiu JA. Torre-Fuentes L, et al. J Med Virol. 2021 Feb;93(2):863-869. doi: 10.1002/jmv.26319. Epub 2020 Jul 28. J Med Virol. 2021. PMID: 32691890 Free PMC article.
Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS-CoV-2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. ...
Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to pr …
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
Kermani NZ, Song WJ, Badi Y, Versi A, Guo Y, Sun K, Bhavsar P, Howarth P, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Chung KF; U-BIOPRED Consortium. Kermani NZ, et al. Respir Res. 2021 Jan 7;22(1):10. doi: 10.1186/s12931-020-01605-8. Respir Res. 2021. PMID: 33413387 Free PMC article.
METHODS: We examined microarray mRNA expression of ACE2, TMPRSS2 and FURIN in sputum, bronchial brushing and bronchial biopsies of the European U-BIOPRED cohort. ...CONCLUSION: Levels of ACE2 and FURIN may differ by clinical or molecular phenotypes of asthma. Sputum …
METHODS: We examined microarray mRNA expression of ACE2, TMPRSS2 and FURIN in sputum, bronchial brushing and bronchial biopsies of th …
Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect.
Cao R, Zhang Y, Du J, Chen S, Wang N, Ying H, Shen B. Cao R, et al. J Clin Lab Anal. 2020 Dec;34(12):e23530. doi: 10.1002/jcla.23530. Epub 2020 Aug 25. J Clin Lab Anal. 2020. PMID: 32840921 Free PMC article.
BACKGROUND: FURIN belongs to the proprotein convertase family that processes proproteins and is involved in many diseases. However, the role of FURIN in rheumatoid arthritis (RA) remains unknown. In this study, we investigated the association between circulat …
BACKGROUND: FURIN belongs to the proprotein convertase family that processes proproteins and is involved in many diseases. How …
Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2.
Diallo I, Jacob RA, Vion E, Kozak RA, Mossman K, Provost P. Diallo I, et al. Viruses. 2023 Feb 10;15(2):496. doi: 10.3390/v15020496. Viruses. 2023. PMID: 36851710 Free PMC article.
Using RT-qPCR, we also showed that SARS-CoV-2 may regulate several predicted host mRNA targets involved in the entry of the virus into host cells (ACE2, TMPRSS2, ADAM17, FURIN), renin-angiotensin system (RAS) (Renin, Angiotensinogen, ACE), innate immune respo …
Using RT-qPCR, we also showed that SARS-CoV-2 may regulate several predicted host mRNA targets involved in the entry of the virus into host …
141 results